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High throughput detection of antibody self-interaction by bio-layer interferometry

Self-interaction of an antibody may lead to aggregation, low solubility or high viscosity. Rapid identification of highly developable leads remains challenging, even though progress has been made with the introduction of techniques such as self-interaction chromatography (SIC) and cross-interaction...

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Autori principali: Sun, Tingwan, Reid, Felicia, Liu, Yuqi, Cao, Yuan, Estep, Patricia, Nauman, Claire, Xu, Yingda
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896597/
https://ncbi.nlm.nih.gov/pubmed/23995620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26186
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