Target-independent variable region mediated effects on antibody clearance can be FcRn independent

The importance of the neonatal Fc receptor (FcRn) in extending the serum half-life of monoclonal antibodies (mAbs) is well demonstrated, and has led to the development of multiple engineering approaches designed to alter Fc interactions with FcRn. Recent reports have additionally highlighted the eff...

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Enregistré dans:
Détails bibliographiques
Publié dans:MAbs
Auteurs principaux: Kelly, Ryan L., Yu, Yao, Sun, Tingwan, Caffry, Isabelle, Lynaugh, Heather, Brown, Michael, Jain, Tushar, Xu, Yingda, Wittrup, K. Dane
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2016
Sujets:
Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058615/
https://ncbi.nlm.nih.gov/pubmed/27610650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1208330
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