Target-independent variable region mediated effects on antibody clearance can be FcRn independent

The importance of the neonatal Fc receptor (FcRn) in extending the serum half-life of monoclonal antibodies (mAbs) is well demonstrated, and has led to the development of multiple engineering approaches designed to alter Fc interactions with FcRn. Recent reports have additionally highlighted the eff...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Kelly, Ryan L., Yu, Yao, Sun, Tingwan, Caffry, Isabelle, Lynaugh, Heather, Brown, Michael, Jain, Tushar, Xu, Yingda, Wittrup, K. Dane
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058615/
https://ncbi.nlm.nih.gov/pubmed/27610650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1208330
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