Target-independent variable region mediated effects on antibody clearance can be FcRn independent

The importance of the neonatal Fc receptor (FcRn) in extending the serum half-life of monoclonal antibodies (mAbs) is well demonstrated, and has led to the development of multiple engineering approaches designed to alter Fc interactions with FcRn. Recent reports have additionally highlighted the eff...

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Bibliografske podrobnosti
izdano v:MAbs
Main Authors: Kelly, Ryan L., Yu, Yao, Sun, Tingwan, Caffry, Isabelle, Lynaugh, Heather, Brown, Michael, Jain, Tushar, Xu, Yingda, Wittrup, K. Dane
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058615/
https://ncbi.nlm.nih.gov/pubmed/27610650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1208330
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