Target-independent variable region mediated effects on antibody clearance can be FcRn independent

The importance of the neonatal Fc receptor (FcRn) in extending the serum half-life of monoclonal antibodies (mAbs) is well demonstrated, and has led to the development of multiple engineering approaches designed to alter Fc interactions with FcRn. Recent reports have additionally highlighted the eff...

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Bibliografski detalji
Izdano u:MAbs
Glavni autori: Kelly, Ryan L., Yu, Yao, Sun, Tingwan, Caffry, Isabelle, Lynaugh, Heather, Brown, Michael, Jain, Tushar, Xu, Yingda, Wittrup, K. Dane
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058615/
https://ncbi.nlm.nih.gov/pubmed/27610650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1208330
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