Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies

Albumin is the most abundant protein in blood and plays a pivotal role as a multitransporter of a wide range of molecules such as fatty acids, metabolites, hormones, and toxins. In addition, it binds a variety of drugs. Its role as distributor is supported by its extraordinary serum half-life of 3 w...

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Bibliographische Detailangaben
Hauptverfasser: Sand, Kine Marita Knudsen, Dalhus, Bjørn, Christianson, Gregory J., Bern, Malin, Foss, Stian, Cameron, Jason, Sleep, Darrell, Bjørås, Magnar, Roopenian, Derry C., Sandlie, Inger, Andersen, Jan Terje
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059163/
https://ncbi.nlm.nih.gov/pubmed/24764301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.522565
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