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Extending Serum Half-life of Albumin by Engineering Neonatal Fc Receptor (FcRn) Binding
A major challenge for the therapeutic use of many peptides and proteins is their short circulatory half-life. Albumin has an extended serum half-life of 3 weeks because of its size and FcRn-mediated recycling that prevents intracellular degradation, properties shared with IgG antibodies. Engineering...
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| 主要な著者: | , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4036356/ https://ncbi.nlm.nih.gov/pubmed/24652290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.549832 |
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