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Extending Serum Half-life of Albumin by Engineering Neonatal Fc Receptor (FcRn) Binding

A major challenge for the therapeutic use of many peptides and proteins is their short circulatory half-life. Albumin has an extended serum half-life of 3 weeks because of its size and FcRn-mediated recycling that prevents intracellular degradation, properties shared with IgG antibodies. Engineering...

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書誌詳細
主要な著者: Andersen, Jan Terje, Dalhus, Bjørn, Viuff, Dorthe, Ravn, Birgitte Thue, Gunnarsen, Kristin Støen, Plumridge, Andrew, Bunting, Karen, Antunes, Filipa, Williamson, Rebecca, Athwal, Steven, Allan, Elizabeth, Evans, Leslie, Bjørås, Magnar, Kjærulff, Søren, Sleep, Darrell, Sandlie, Inger, Cameron, Jason
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036356/
https://ncbi.nlm.nih.gov/pubmed/24652290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.549832
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