Extending Serum Half-life of Albumin by Engineering Neonatal Fc Receptor (FcRn) Binding

A major challenge for the therapeutic use of many peptides and proteins is their short circulatory half-life. Albumin has an extended serum half-life of 3 weeks because of its size and FcRn-mediated recycling that prevents intracellular degradation, properties shared with IgG antibodies. Engineering...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Andersen, Jan Terje, Dalhus, Bjørn, Viuff, Dorthe, Ravn, Birgitte Thue, Gunnarsen, Kristin Støen, Plumridge, Andrew, Bunting, Karen, Antunes, Filipa, Williamson, Rebecca, Athwal, Steven, Allan, Elizabeth, Evans, Leslie, Bjørås, Magnar, Kjærulff, Søren, Sleep, Darrell, Sandlie, Inger, Cameron, Jason
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036356/
https://ncbi.nlm.nih.gov/pubmed/24652290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.549832
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky