Extending Serum Half-life of Albumin by Engineering Neonatal Fc Receptor (FcRn) Binding

A major challenge for the therapeutic use of many peptides and proteins is their short circulatory half-life. Albumin has an extended serum half-life of 3 weeks because of its size and FcRn-mediated recycling that prevents intracellular degradation, properties shared with IgG antibodies. Engineering...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Andersen, Jan Terje, Dalhus, Bjørn, Viuff, Dorthe, Ravn, Birgitte Thue, Gunnarsen, Kristin Støen, Plumridge, Andrew, Bunting, Karen, Antunes, Filipa, Williamson, Rebecca, Athwal, Steven, Allan, Elizabeth, Evans, Leslie, Bjørås, Magnar, Kjærulff, Søren, Sleep, Darrell, Sandlie, Inger, Cameron, Jason
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036356/
https://ncbi.nlm.nih.gov/pubmed/24652290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.549832
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