High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

Although improvements in technology for the isolation of potential therapeutic antibodies have made the process increasingly predictable, the development of biologically active monoclonal antibodies (mAbs) into drugs can often be impeded by developability issues such as poor expression, solubility,...

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Publicado en:MAbs
Main Authors: Kelly, Ryan L, Sun, Tingwan, Jain, Tushar, Caffry, Isabelle, Yu, Yao, Cao, Yuan, Lynaugh, Heather, Brown, Michael, Vásquez, Maximiliano, Wittrup, K Dane, Xu, Yingda
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622737/
https://ncbi.nlm.nih.gov/pubmed/26047159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1043503
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