High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

Although improvements in technology for the isolation of potential therapeutic antibodies have made the process increasingly predictable, the development of biologically active monoclonal antibodies (mAbs) into drugs can often be impeded by developability issues such as poor expression, solubility,...

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Gepubliceerd in:MAbs
Hoofdauteurs: Kelly, Ryan L, Sun, Tingwan, Jain, Tushar, Caffry, Isabelle, Yu, Yao, Cao, Yuan, Lynaugh, Heather, Brown, Michael, Vásquez, Maximiliano, Wittrup, K Dane, Xu, Yingda
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2015
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Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622737/
https://ncbi.nlm.nih.gov/pubmed/26047159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1043503
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