Massive Bioaccumulation and Self‐Assembly of Phenazine Compounds in Live Cells

Clofazimine is an orally administered drug that massively bioaccumulates in macrophages, forming membrane‐bound intracellular structures possessing nanoscale supramolecular features. Here, a library of phenazine compounds derived from clofazimine is synthesized and tested for ability to accumulate a...

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Vydáno v:Adv Sci (Weinh)
Hlavní autoři: Min, Kyoung Ah, Rajeswaran, Walajapet G., Oldenbourg, Rudolf, Harris, Grant, Keswani, Rahul K., Chiang, Mason, Rzeczycki, Phillip, Talattof, Arjang, Hafeez, Mahwish, Horobin, Richard W., Larsen, Scott D., Stringer, Kathleen A., Rosania, Gus R.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569013/
https://ncbi.nlm.nih.gov/pubmed/26380168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201500025
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