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Detecting ordered small molecule drug aggregates in live macrophages: a multi-parameter microscope image data acquisition and analysis strategy

Following prolonged administration, certain orally bioavailable but poorly soluble small molecule drugs are prone to precipitate out and form crystal-like drug inclusions (CLDIs) within the cells of living organisms. In this research, we present a quantitative multi-parameter imaging platform for me...

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Bibliografiske detaljer
Udgivet i:Biomed Opt Express
Main Authors: Rzeczycki, Phillip, Yoon, Gi Sang, Keswani, Rahul K., Sud, Sudha, Stringer, Kathleen A., Rosania, Gus R.
Format: Artigo
Sprog:Inglês
Udgivet: Optical Society of America 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330574/
https://ncbi.nlm.nih.gov/pubmed/28270989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1364/BOE.8.000860
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