Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State

Clofazimine (CFZ) is a poorly soluble antibiotic and anti-inflammatory drug indicated for the treatment of leprosy. In spite of its therapeutic value, CFZ therapy is accompanied by the formation of drug biocrystals that accumulate within resident tissue macrophages, without obvious toxicological man...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Yoon, Gi S., Keswani, Rahul K., Sud, Sudha, Rzeczycki, Phillip M., Murashov, Mikhail D., Koehn, Tony A., Standiford, Theodore J., Stringer, Kathleen A., Rosania, Gus R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879385/
https://ncbi.nlm.nih.gov/pubmed/27021320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00265-16
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