Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State

Clofazimine (CFZ) is a poorly soluble antibiotic and anti-inflammatory drug indicated for the treatment of leprosy. In spite of its therapeutic value, CFZ therapy is accompanied by the formation of drug biocrystals that accumulate within resident tissue macrophages, without obvious toxicological man...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Yoon, Gi S., Keswani, Rahul K., Sud, Sudha, Rzeczycki, Phillip M., Murashov, Mikhail D., Koehn, Tony A., Standiford, Theodore J., Stringer, Kathleen A., Rosania, Gus R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2016
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Mechanisms of Action: Physiological Effects
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879385/
https://ncbi.nlm.nih.gov/pubmed/27021320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00265-16
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