Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State

Clofazimine (CFZ) is a poorly soluble antibiotic and anti-inflammatory drug indicated for the treatment of leprosy. In spite of its therapeutic value, CFZ therapy is accompanied by the formation of drug biocrystals that accumulate within resident tissue macrophages, without obvious toxicological man...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Yoon, Gi S., Keswani, Rahul K., Sud, Sudha, Rzeczycki, Phillip M., Murashov, Mikhail D., Koehn, Tony A., Standiford, Theodore J., Stringer, Kathleen A., Rosania, Gus R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Mechanisms of Action: Physiological Effects
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879385/
https://ncbi.nlm.nih.gov/pubmed/27021320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00265-16
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