Multiscale Distribution and Bioaccumulation Analysis of Clofazimine Reveals a Massive Immune System-Mediated Xenobiotic Sequestration Response

Chronic exposure to some well-absorbed but slowly eliminated xenobiotics can lead to their bioaccumulation in living organisms. Here, we studied the bioaccumulation and distribution of clofazimine, a riminophenazine antibiotic used to treat mycobacterial infection. Using mice as a model organism, we...

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Autors principals: Baik, Jason, Stringer, Kathleen A., Mane, Gerta, Rosania, Gus R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591914/
https://ncbi.nlm.nih.gov/pubmed/23263006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01731-12
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