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Macrophage-Mediated Clofazimine Sequestration is Accompanied by a Shift in Host Energy Metabolism
Prolonged (8 weeks) oral administration of clofazimine results in a profound pharmacodynamic response- bioaccumulation in macrophages (including Kupffer cells) as intracellular crystal-like drug inclusions (CLDIs) with an associated increase in interleukin-1 receptor antagonist production. Notably,...
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| 出版年: | J Pharm Sci |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5357462/ https://ncbi.nlm.nih.gov/pubmed/28007559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.12.009 |
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