Macrophage-Mediated Clofazimine Sequestration is Accompanied by a Shift in Host Energy Metabolism

Prolonged (8 weeks) oral administration of clofazimine results in a profound pharmacodynamic response- bioaccumulation in macrophages (including Kupffer cells) as intracellular crystal-like drug inclusions (CLDIs) with an associated increase in interleukin-1 receptor antagonist production. Notably,...

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Publicado en:J Pharm Sci
Main Authors: Trexel, Julie, Yoon, Gi S., Keswani, Rahul K., McHugh, Cora, Yeomans, Larisa, Vitvitsky, Victor, Banerjee, Ruma, Sud, Sudha, Sun, Yihan, Rosania, Gus R., Stringer, Kathleen A.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357462/
https://ncbi.nlm.nih.gov/pubmed/28007559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.12.009
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