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Macrophage-Mediated Clofazimine Sequestration is Accompanied by a Shift in Host Energy Metabolism
Prolonged (8 weeks) oral administration of clofazimine results in a profound pharmacodynamic response- bioaccumulation in macrophages (including Kupffer cells) as intracellular crystal-like drug inclusions (CLDIs) with an associated increase in interleukin-1 receptor antagonist production. Notably,...
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Publicado no: | J Pharm Sci |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5357462/ https://ncbi.nlm.nih.gov/pubmed/28007559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.12.009 |
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