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The Extracellular Microenvironment Explains Variations in Passive Drug Transport across Different Airway Epithelial Cell Types

PURPOSE: We sought to identify key variables in cellular architecture and physiology that might explain observed differences in the passive transport properties of small molecule drugs across different airway epithelial cell types. METHODS: Propranolol (PR) was selected as a weakly basic, model comp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Min, Kyoung Ah, Talattof, Arjang, Tsume, Yasuhiro, Stringer, Kathleen A., Yu, Jing-yu, Lim, Dong Hyun, Rosania, Gus R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706189/
https://ncbi.nlm.nih.gov/pubmed/23708857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1069-5
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