Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease

Gaucher’s disease is caused by defects in acid β-glucosidase 1 (GBA1) and has been also proposed as an inflammatory disease. GBA1 cleaves glucosylceramide to form ceramide, an established bioactive lipid, and defects in GBA1 lead to aberrant accumulation in glucosylceramide and insufficient formatio...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Kitatani, Kazuyuki, Wada, Masayuki, Perry, David, Usui, Toshinori, Sun, Ying, Obeid, Lina M., Yaegashi, Nobuo, Grabowski, Gregory A., Hannun, Yusuf A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552301/
https://ncbi.nlm.nih.gov/pubmed/26312487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136633
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