Acid β-Glucosidase 1 Counteracts p38δ-dependent Induction of Interleukin-6: POSSIBLE ROLE FOR CERAMIDE AS AN ANTI-INFLAMMATORY LIPID

Activation of protein kinase C (PKC) by the phorbol ester (phorbol 12-myristate 13-acetate) induces ceramide formation through the salvage pathway involving, in part, acid β-glucosidase 1 (GBA1), which cleaves glucosylceramide to ceramide. Here, we examine the role of the GBA1-ceramide pathway, in r...

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Detalhes bibliográficos
Main Authors: Kitatani, Kazuyuki, Sheldon, Kely, Anelli, Viviana, Jenkins, Russell W., Sun, Ying, Grabowski, Gregory A., Obeid, Lina M., Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676030/
https://ncbi.nlm.nih.gov/pubmed/19279008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809500200
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