Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

Mammalian ceramide synthases 1 to 6 (CerS1–6) generate Cer in an acyl-CoA-dependent manner, and expression of individual CerS has been shown to enhance the synthesis of ceramides with particular acyl chain lengths. However, the contribution of each CerS to steady-state levels of specific Cer species...

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Main Authors: Mullen, Thomas D., Spassieva, Stefka, Jenkins, Russell W., Kitatani, Kazuyuki, Bielawski, Jacek, Hannun, Yusuf A., Obeid, Lina M.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2011
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999923/
https://ncbi.nlm.nih.gov/pubmed/20940143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M009142
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