Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation

Sphingosine kinase 1 (SK1) produces the pro-survival sphingolipid sphingosine 1-phosphate and has been implicated in inflammation, proliferation, and angiogenesis. Recent studies identified TRAF2 as a sphingosine 1-phosphate target, implicating SK1 in activation of the NF-κB pathway, but the functio...

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Hlavní autoři: Adada, Mohamad M., Orr-Gandy, K. Alexa, Snider, Ashley J., Canals, Daniel, Hannun, Yusuf A., Obeid, Lina M., Clarke, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779762/
https://ncbi.nlm.nih.gov/pubmed/23935096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.489443
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