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Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3

The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-sensing cysteines within p38α. p38α was activ...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bassi, Rekha, Burgoyne, Joseph R., DeNicola, Gian F., Rudyk, Olena, DeSantis, Vittorio, Charles, Rebecca L., Eaton, Philip, Marber, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625047/
https://ncbi.nlm.nih.gov/pubmed/28739872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785410
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