Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3

The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-sensing cysteines within p38α. p38α was activ...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Bassi, Rekha, Burgoyne, Joseph R., DeNicola, Gian F., Rudyk, Olena, DeSantis, Vittorio, Charles, Rebecca L., Eaton, Philip, Marber, Michael S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625047/
https://ncbi.nlm.nih.gov/pubmed/28739872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785410
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