The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning

Numerous studies show that pharmacological inhibition of p38 mitogen-activated protein kinases (p38s) before lethal ischemia prevents conditioning. However, these inhibitors have off-target effects and do not discriminate between the alpha and beta isoforms; the activation of which is thought to hav...

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Bibliografiske detaljer
Main Authors: Sicard, Pierre, Clark, James E., Jacquet, Sebastien, Mohammadi, Shahrooz, Arthur, J. Simon C., O'Keefe, Stephen J., Marber, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: Academic Press 2010
Fag:
Rapid Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877771/
https://ncbi.nlm.nih.gov/pubmed/20188737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.02.013
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