A Chemical Genetic Approach Reveals That p38α MAPK Activation by Diphosphorylation Aggravates Myocardial Infarction and Is Prevented by the Direct Binding of SB203580

The use of nonselective pharmacological inhibitors has resulted in controversy regarding the mechanism and consequences of p38 activation during myocardial infarction. Classic p38 inhibitors such as SB203580 rely on a critical “gatekeeper” threonine residue for binding. We addressed these controvers...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kumphune, Sarawut, Bassi, Rekha, Jacquet, Sebastien, Sicard, Pierre, Clark, James E., Verma, Sharwari, Avkiran, Metin, O'Keefe, Stephen J., Marber, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823430/
https://ncbi.nlm.nih.gov/pubmed/19996096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.079228
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados