A Chemical Genetic Approach Reveals That p38α MAPK Activation by Diphosphorylation Aggravates Myocardial Infarction and Is Prevented by the Direct Binding of SB203580

The use of nonselective pharmacological inhibitors has resulted in controversy regarding the mechanism and consequences of p38 activation during myocardial infarction. Classic p38 inhibitors such as SB203580 rely on a critical “gatekeeper” threonine residue for binding. We addressed these controvers...

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Main Authors: Kumphune, Sarawut, Bassi, Rekha, Jacquet, Sebastien, Sicard, Pierre, Clark, James E., Verma, Sharwari, Avkiran, Metin, O'Keefe, Stephen J., Marber, Michael S.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
主題:
Mechanisms of Signal Transduction
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823430/
https://ncbi.nlm.nih.gov/pubmed/19996096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.079228
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