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Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease
Gaucher’s disease is caused by defects in acid β-glucosidase 1 (GBA1) and has been also proposed as an inflammatory disease. GBA1 cleaves glucosylceramide to form ceramide, an established bioactive lipid, and defects in GBA1 lead to aberrant accumulation in glucosylceramide and insufficient formatio...
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| 出版年: | PLoS One |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4552301/ https://ncbi.nlm.nih.gov/pubmed/26312487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136633 |
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