Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease. Pancreaticoduodenectomy offers patients the possibility of a cu...

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Publicat a:EMBO Mol Med
Autors principals: Miller, Bryan W, Morton, Jennifer P, Pinese, Mark, Saturno, Grazia, Jamieson, Nigel B, McGhee, Ewan, Timpson, Paul, Leach, Joshua, McGarry, Lynn, Shanks, Emma, Bailey, Peter, Chang, David, Oien, Karin, Karim, Saadia, Au, Amy, Steele, Colin, Carter, Christopher Ross, McKay, Colin, Anderson, Kurt, Evans, Thomas R Jeffry, Marais, Richard, Springer, Caroline, Biankin, Andrew, Erler, Janine T, Sansom, Owen J
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551344/
https://ncbi.nlm.nih.gov/pubmed/26077591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404827
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