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LOX-1 abrogation reduces cardiac hypertrophy and collagen accumulation following chronic ischemia in the mouse
We hypothesized that lectin-like oxidized LDL receptor-1 (LOX-1) deletion may inhibit oxidative stress signals, reduce collagen accumulation and attenuate cardiac remodeling after chronic ischemia. Activation of LOX-1 plays a significant role in the development of inflammation, apoptosis and collage...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4045006/ https://ncbi.nlm.nih.gov/pubmed/21938018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.133 |
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