LOX-1 abrogation reduces cardiac hypertrophy and collagen accumulation following chronic ischemia in the mouse

We hypothesized that lectin-like oxidized LDL receptor-1 (LOX-1) deletion may inhibit oxidative stress signals, reduce collagen accumulation and attenuate cardiac remodeling after chronic ischemia. Activation of LOX-1 plays a significant role in the development of inflammation, apoptosis and collage...

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Hlavní autoři: Lu, J, Wang, X, Wang, W, Muniyappa, H, Hu, C, Mitra, S, Long, B, Das, K, Mehta, JL
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045006/
https://ncbi.nlm.nih.gov/pubmed/21938018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.133
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