DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication. UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also repressive H3K9me3 histone marks with its TTD. With systematic mutagenesis and functional assays, we could show that chromatin binding furth...

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Dettagli Bibliografici
Pubblicato in:Cell Res
Autori principali: Qin, Weihua, Wolf, Patricia, Liu, Nan, Link, Stephanie, Smets, Martha, Mastra, Federica La, Forné, Ignasi, Pichler, Garwin, Hörl, David, Fellinger, Karin, Spada, Fabio, Bonapace, Ian Marc, Imhof, Axel, Harz, Hartmann, Leonhardt, Heinrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528052/
https://ncbi.nlm.nih.gov/pubmed/26065575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.72
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