The multi-domain protein Np95 connects DNA methylation and histone modification

DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. Recently, Np95 (also known as UHRF1 or ICBP90) has been found to interact with Dnmt1 and to bind hemimethylated DNA, indicating together with genetic studies a cent...

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Bibliographic Details
Main Authors: Rottach, Andrea, Frauer, Carina, Pichler, Garwin, Bonapace, Ian Marc, Spada, Fabio, Leonhardt, Heinrich
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847221/
https://ncbi.nlm.nih.gov/pubmed/20026581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1152
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