DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation

DNMT1 is recruited to substrate sites by PCNA and UHRF1 to maintain DNA methylation after replication. The cell cycle dependent recruitment of DNMT1 is mediated by the PCNA-binding domain (PBD) and the targeting sequence (TS) within the N-terminal regulatory domain. The TS domain was found to be mut...

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Bibliografische gegevens
Gepubliceerd in:Hum Mol Genet
Hoofdauteurs: Smets, Martha, Link, Stephanie, Wolf, Patricia, Schneider, Katrin, Solis, Veronica, Ryan, Joel, Meilinger, Daniela, Qin, Weihua, Leonhardt, Heinrich
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393148/
https://ncbi.nlm.nih.gov/pubmed/28334952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx057
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