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DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation
DNMT1 is recruited to substrate sites by PCNA and UHRF1 to maintain DNA methylation after replication. The cell cycle dependent recruitment of DNMT1 is mediated by the PCNA-binding domain (PBD) and the targeting sequence (TS) within the N-terminal regulatory domain. The TS domain was found to be mut...
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| Izdano u: | Hum Mol Genet |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5393148/ https://ncbi.nlm.nih.gov/pubmed/28334952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx057 |
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