DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation

DNMT1 is recruited to substrate sites by PCNA and UHRF1 to maintain DNA methylation after replication. The cell cycle dependent recruitment of DNMT1 is mediated by the PCNA-binding domain (PBD) and the targeting sequence (TS) within the N-terminal regulatory domain. The TS domain was found to be mut...

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Detaylı Bibliyografya
Yayımlandı:Hum Mol Genet
Asıl Yazarlar: Smets, Martha, Link, Stephanie, Wolf, Patricia, Schneider, Katrin, Solis, Veronica, Ryan, Joel, Meilinger, Daniela, Qin, Weihua, Leonhardt, Heinrich
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393148/
https://ncbi.nlm.nih.gov/pubmed/28334952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx057
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