DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication. UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also repressive H3K9me3 histone marks with its TTD. With systematic mutagenesis and functional assays, we could show that chromatin binding furth...

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Publicat a:Cell Res
Autors principals: Qin, Weihua, Wolf, Patricia, Liu, Nan, Link, Stephanie, Smets, Martha, Mastra, Federica La, Forné, Ignasi, Pichler, Garwin, Hörl, David, Fellinger, Karin, Spada, Fabio, Bonapace, Ian Marc, Imhof, Axel, Harz, Hartmann, Leonhardt, Heinrich
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528052/
https://ncbi.nlm.nih.gov/pubmed/26065575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.72
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