Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

Recent studies have indicated that nuclear protein of 95 kDa (Np95) is essential for maintaining genomic methylation by recruiting DNA methyltransferase (Dnmt) 1 to hemi-methylated sites. Here, we show that Np95 interacts more strongly with regulatory domains of the de novo methyltransferases Dnmt3a...

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Bibliographische Detailangaben
Hauptverfasser: Meilinger, Daniela, Fellinger, Karin, Bultmann, Sebastian, Rothbauer, Ulrich, Bonapace, Ian Marc, Klinkert, Wolfgang E F, Spada, Fabio, Leonhardt, Heinrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756565/
https://ncbi.nlm.nih.gov/pubmed/19798101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.201
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