Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

Recent studies have indicated that nuclear protein of 95 kDa (Np95) is essential for maintaining genomic methylation by recruiting DNA methyltransferase (Dnmt) 1 to hemi-methylated sites. Here, we show that Np95 interacts more strongly with regulatory domains of the de novo methyltransferases Dnmt3a...

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Detalhes bibliográficos
Main Authors: Meilinger, Daniela, Fellinger, Karin, Bultmann, Sebastian, Rothbauer, Ulrich, Bonapace, Ian Marc, Klinkert, Wolfgang E F, Spada, Fabio, Leonhardt, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756565/
https://ncbi.nlm.nih.gov/pubmed/19798101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.201
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