DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication. UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also repressive H3K9me3 histone marks with its TTD. With systematic mutagenesis and functional assays, we could show that chromatin binding furth...

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Detaylı Bibliyografya
Yayımlandı:Cell Res
Asıl Yazarlar: Qin, Weihua, Wolf, Patricia, Liu, Nan, Link, Stephanie, Smets, Martha, Mastra, Federica La, Forné, Ignasi, Pichler, Garwin, Hörl, David, Fellinger, Karin, Spada, Fabio, Bonapace, Ian Marc, Imhof, Axel, Harz, Hartmann, Leonhardt, Heinrich
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528052/
https://ncbi.nlm.nih.gov/pubmed/26065575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.72
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