DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication. UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also repressive H3K9me3 histone marks with its TTD. With systematic mutagenesis and functional assays, we could show that chromatin binding furth...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Qin, Weihua, Wolf, Patricia, Liu, Nan, Link, Stephanie, Smets, Martha, Mastra, Federica La, Forné, Ignasi, Pichler, Garwin, Hörl, David, Fellinger, Karin, Spada, Fabio, Bonapace, Ian Marc, Imhof, Axel, Harz, Hartmann, Leonhardt, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528052/
https://ncbi.nlm.nih.gov/pubmed/26065575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.72
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