Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency

Heterochromatin binding protein HP1β plays an important role in chromatin organization and cell differentiation, however the underlying mechanisms remain unclear. Here, we generated HP1β(−/−) embryonic stem cells and observed reduced heterochromatin clustering and impaired differentiation. We found...

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Foilsithe in:Nucleic Acids Res
Main Authors: Qin, Weihua, Ugur, Enes, Mulholland, Christopher B, Bultmann, Sebastian, Solovei, Irina, Modic, Miha, Smets, Martha, Wierer, Michael, Forné, Ignasi, Imhof, Axel, Cardoso, M Cristina, Leonhardt, Heinrich
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2021
Ábhair:
Gene regulation, Chromatin and Epigenetics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287961/
https://ncbi.nlm.nih.gov/pubmed/34214177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab548
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