Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency

Heterochromatin binding protein HP1β plays an important role in chromatin organization and cell differentiation, however the underlying mechanisms remain unclear. Here, we generated HP1β(−/−) embryonic stem cells and observed reduced heterochromatin clustering and impaired differentiation. We found...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Qin, Weihua, Ugur, Enes, Mulholland, Christopher B, Bultmann, Sebastian, Solovei, Irina, Modic, Miha, Smets, Martha, Wierer, Michael, Forné, Ignasi, Imhof, Axel, Cardoso, M Cristina, Leonhardt, Heinrich
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287961/
https://ncbi.nlm.nih.gov/pubmed/34214177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab548
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