Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency

Heterochromatin binding protein HP1β plays an important role in chromatin organization and cell differentiation, however the underlying mechanisms remain unclear. Here, we generated HP1β(−/−) embryonic stem cells and observed reduced heterochromatin clustering and impaired differentiation. We found...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Qin, Weihua, Ugur, Enes, Mulholland, Christopher B, Bultmann, Sebastian, Solovei, Irina, Modic, Miha, Smets, Martha, Wierer, Michael, Forné, Ignasi, Imhof, Axel, Cardoso, M Cristina, Leonhardt, Heinrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287961/
https://ncbi.nlm.nih.gov/pubmed/34214177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab548
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