Dissection of cell cycle–dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling

DNA methyltransferase 1 (Dnmt1) reestablishes methylation of hemimethylated CpG sites generated during DNA replication in mammalian cells. Two subdomains, the proliferating cell nuclear antigen (PCNA)-binding domain (PBD) and the targeting sequence (TS) domain, target Dnmt1 to the replication sites...

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Bibliografiska uppgifter
Huvudupphovsmän: Schneider, Katrin, Fuchs, Christiane, Dobay, Akos, Rottach, Andrea, Qin, Weihua, Wolf, Patricia, Álvarez-Castro, José M., Nalaskowski, Marcus M., Kremmer, Elisabeth, Schmid, Volker, Leonhardt, Heinrich, Schermelleh, Lothar
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2013
Ämnen:
Gene Regulation, Chromatin and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643600/
https://ncbi.nlm.nih.gov/pubmed/23535145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt191
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