Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression

Transcriptional regulators are recurrently altered through translocations, deletions, or aberrant expression in acute myeloid leukemia (AML). Although critically important in leukemogenesis, the underlying pathogenetic mechanisms they trigger remain largely unknown. Here, we identified that Id1 (inh...

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Veröffentlicht in:Blood
Hauptverfasser: Wang, Lan, Man, Na, Sun, Xiao-Jian, Tan, Yurong, Cao, Marta Garcia, Liu, Fan, Hatlen, Megan, Xu, Haiming, Huang, Gang, Mattlin, Meredith, Mehta, Arpit, Rampersaud, Evadnie, Benezra, Robert, Nimer, Stephen D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520879/
https://ncbi.nlm.nih.gov/pubmed/26084673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-635532
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