Negative effects of GM-CSF signaling in a murine model of t(8;21)–induced leukemia

The t(8;21)(q22;q22) is common in adult acute myeloid leukemia (AML). The RUNX1-ETO fusion protein that is expressed by this translocation is poorly leukemogenic and requires additional mutations for transformation. Loss of sex chromosome (LOS) is frequently observed in t(8;21) AML. In the present s...

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Autori principali: Matsuura, Shinobu, Yan, Ming, Lo, Miao-Chia, Ahn, Eun-Young, Weng, Stephanie, Dangoor, David, Matin, Mahan, Higashi, Tsunehito, Feng, Gen-Sheng, Zhang, Dong-Er
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321875/
https://ncbi.nlm.nih.gov/pubmed/22223820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-350694
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