Restoration of MYC-repressed targets mediates the negative effects of GM-CSF on RUNX1-ETO leukemogenicity

GM-CSF signaling regulates hematopoiesis and immune responses. CSF2RA, the gene encoding the α subunit for GM-CSF, is significantly downregulated in t(8;21) (RUNX1-ETO or RE) leukemia patients, suggesting that it may serve as a tumor suppressor. We previously reported that GM-CSF signaling is inhibi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Leukemia
Main Authors: Weng, Stephanie, Matsuura, Shinobu, Mowery, Cody T., Stoner, Samuel A., Lam, Kentson, Ran, Dan, Davis, Amanda G., Lo, Miao-Chia, Zhang, Dong-Er
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214981/
https://ncbi.nlm.nih.gov/pubmed/27389055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.167
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker