Restoration of MYC-repressed targets mediates the negative effects of GM-CSF on RUNX1-ETO leukemogenicity

GM-CSF signaling regulates hematopoiesis and immune responses. CSF2RA, the gene encoding the α subunit for GM-CSF, is significantly downregulated in t(8;21) (RUNX1-ETO or RE) leukemia patients, suggesting that it may serve as a tumor suppressor. We previously reported that GM-CSF signaling is inhibi...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Weng, Stephanie, Matsuura, Shinobu, Mowery, Cody T., Stoner, Samuel A., Lam, Kentson, Ran, Dan, Davis, Amanda G., Lo, Miao-Chia, Zhang, Dong-Er
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214981/
https://ncbi.nlm.nih.gov/pubmed/27389055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.167
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