Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML

Chromosome translocation 8q22;21q22 [t(8;21)] is commonly associated with acute myeloid leukemia (AML), and the resulting AML1-ETO fusion proteins are involved in the pathogenesis of AML. To identify novel molecular and therapeutic targets, we performed combined gene expression microarray and promot...

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Bibliografiska uppgifter
Huvudupphovsmän: Lo, Miao-Chia, Peterson, Luke F., Yan, Ming, Cong, Xiuli, Jin, Fulai, Shia, Wei-Jong, Matsuura, Shinobu, Ahn, Eun-Young, Komeno, Yukiko, Ly, Minh, Ommen, Hans B., Chen, I-Ming, Hokland, Peter, Willman, Cheryl L., Ren, Bing, Zhang, Dong-Er
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2012
Ämnen:
Myeloid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423785/
https://ncbi.nlm.nih.gov/pubmed/22740448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-395335
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