Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome

Mutations of RUNX1 are detected in patients with myelodysplastic syndrome (MDS). In particular, C-terminal truncation mutations lack a transcription regulatory domain and have increased DNA binding through the runt homology domain. The expression of the runt homology domain, RUNX1(41-214), in mouse...

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Detalhes bibliográficos
Main Authors: Matsuura, Shinobu, Komeno, Yukiko, Stevenson, Kristen E., Biggs, Joseph R., Lam, Kentson, Tang, Tingdong, Lo, Miao-Chia, Cong, Xiuli, Yan, Ming, Neuberg, Donna S., Zhang, Dong-Er
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496957/
https://ncbi.nlm.nih.gov/pubmed/22919028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-404533
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