Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome

Mutations of RUNX1 are detected in patients with myelodysplastic syndrome (MDS). In particular, C-terminal truncation mutations lack a transcription regulatory domain and have increased DNA binding through the runt homology domain. The expression of the runt homology domain, RUNX1(41-214), in mouse...

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Bibliografische gegevens
Hoofdauteurs: Matsuura, Shinobu, Komeno, Yukiko, Stevenson, Kristen E., Biggs, Joseph R., Lam, Kentson, Tang, Tingdong, Lo, Miao-Chia, Cong, Xiuli, Yan, Ming, Neuberg, Donna S., Zhang, Dong-Er
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2012
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496957/
https://ncbi.nlm.nih.gov/pubmed/22919028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-404533
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