Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome

Mutations of RUNX1 are detected in patients with myelodysplastic syndrome (MDS). In particular, C-terminal truncation mutations lack a transcription regulatory domain and have increased DNA binding through the runt homology domain. The expression of the runt homology domain, RUNX1(41-214), in mouse...

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Main Authors: Matsuura, Shinobu, Komeno, Yukiko, Stevenson, Kristen E., Biggs, Joseph R., Lam, Kentson, Tang, Tingdong, Lo, Miao-Chia, Cong, Xiuli, Yan, Ming, Neuberg, Donna S., Zhang, Dong-Er
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496957/
https://ncbi.nlm.nih.gov/pubmed/22919028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-404533
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