Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts

Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on...

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Bibliographic Details
Main Authors: Peterson, Luke F., Boyapati, Anita, Ahn, Eun-Young, Biggs, Joseph R., Okumura, Akiko Joo, Lo, Miao-Chia, Yan, Ming, Zhang, Dong-Er
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2007
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924771/
https://ncbi.nlm.nih.gov/pubmed/17412887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-11-019265
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