Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression

Transcriptional regulators are recurrently altered through translocations, deletions, or aberrant expression in acute myeloid leukemia (AML). Although critically important in leukemogenesis, the underlying pathogenetic mechanisms they trigger remain largely unknown. Here, we identified that Id1 (inh...

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Bibliographic Details
Published in:Blood
Main Authors: Wang, Lan, Man, Na, Sun, Xiao-Jian, Tan, Yurong, Cao, Marta Garcia, Liu, Fan, Hatlen, Megan, Xu, Haiming, Huang, Gang, Mattlin, Meredith, Mehta, Arpit, Rampersaud, Evadnie, Benezra, Robert, Nimer, Stephen D.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520879/
https://ncbi.nlm.nih.gov/pubmed/26084673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-635532
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