Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression

Transcriptional regulators are recurrently altered through translocations, deletions, or aberrant expression in acute myeloid leukemia (AML). Although critically important in leukemogenesis, the underlying pathogenetic mechanisms they trigger remain largely unknown. Here, we identified that Id1 (inh...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Wang, Lan, Man, Na, Sun, Xiao-Jian, Tan, Yurong, Cao, Marta Garcia, Liu, Fan, Hatlen, Megan, Xu, Haiming, Huang, Gang, Mattlin, Meredith, Mehta, Arpit, Rampersaud, Evadnie, Benezra, Robert, Nimer, Stephen D.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2015
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520879/
https://ncbi.nlm.nih.gov/pubmed/26084673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-635532
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